This paper combines the industrial background of Grimsby, the tidal flooding problem and geomorphology of the Humber Estuary, and an innovative approach to study the combination of aquaculture and managed realignment areas. Tidal simulation is used to study the effect of increasing the managed realignment areas on flood hazard. Based on the physical conditions of the Humber Estuary, shellfish species and aquaculture methods, the mapping of potential aquaculture areas in Grimsby are explored. We focused on the interaction between aquaculture and managed realignment areas. Via planning and designing the distribution mode of aquaculture farms, our objective was to find the optimal scheme which could have a positive impact on the managed realignment areas. At the same time, GIS software and CAESAR software are used together to simulate tidal flooding and extract information, such as water velocity, water direction, erosion and deposition process, and then import this information into GIS for processing to visualize the simulation information.